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\newlist{questionlist}{enumerate}{3}
\setlist[questionlist,1]{label*=\arabic*,ref=\arabic*}
\setlist[questionlist,2]{label*=.\arabic*,ref=\arabic{questionlisti}.\arabic*}
\setlist[questionlist,3]{label*=.\arabic*,ref=\arabic{questionlisti}.\arabic{questionlistii}.\arabic*}

\begin{questionlist}
\item \textbf{Topic} \label{question:label} Question? \pageref{answer:label}
\begin{questionlist}
\end{questionlist}

\marginpar{
  This answers Question \ref{question:label} \label{answer:label}
}